Transdrug Selected Scientific Papers
Sangro B. Refined tools for the treatment of hepatocellular carcinoma. J Hepatol. 2005 May; 42(5): 629-31. View Abstract on PubMed
Barraud L, Merle P, Soma E, Lefrançois L, Guerret S, Chevallier M, Dubernet C, Couvreur P, Trépo C, Vitvitski L. Increase of doxorubicin sensitivity by doxorubicin-loading into nanoparticles for hepatocellular carcinoma cells in vitro and in vivo. J Hepatol. 2005 May; 42(5): 736-43. View Abstract on PubMed
Laurand A, Laroche-Clary A, Larrue A, Huet S, Soma E, Bonnet
J, Robert J. Quantification of the expression of multidrug
resistance-related genes in human tumour cell lines grown
with free doxorubicin or doxorubicin encapsulated in polyisohexylcyanoacrylate
nanospheres. Anticancer Res. 2004 Nov-Dec; 24(6): 3781-8.
View Abstract on PubMed
N. Aouali, H. Morjani, E. Soma, D. Costantini, M. Manfait. Enhanced cytotoxicity and nuclear accumulation of doxorubicin-loaded nanospheres in human breast cancer MCF7 cells expressing MRP1. Int J Oncol. 2003 Oct; 23 (4): 1195-201. View Abstract on PubMed.
Dembri A, Montisci MJ, Gantier JC, Chacun H, Ponchel G. Targeting of 3'-azido 3'-deoxythymidine (AZT)-loaded poly(isohexylcyanoacrylate) nanospheres to the gastrointestinal mucosa and associated lymphoid tissues. Pharm Res. 2001 Apr; 18(4): 467-73. View Abstract on PubMed.
Laurand A, Laroche-Clary A, Larrue A, Bonnet J, Robert J. Quantification of the expression of the multidrug-resistance related genes MDR1, MRP1, BCRP and TOPO II in K562 and MCF7 sublines grown with free doxorubicin or doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres. Proceedings of the American Association for Cancer Research (March 2001) Vol. 42.
Soma CE, Dubernet C, Barratt G, Benita S, Couvreur P. Investigation of the role of macrophages on the cytotoxicity of doxorubicin and doxorubicin-loaded nanoparticles on M5076 cells in vitro. J Control Release . 2000 Aug 10; 68(2): 283-9. View Abstract on PubMed.
Soma CE, Dubernet C, Barratt G, Nemati F, Appel M, Benita S and Couvreur P. Ability of doxorubicin-loaded nanoparticles to overcome multidrug resistance of tumor cells after their capture by macrophages Pharm Res. 1999 Nov; 16 (11): 1710-6. View Abstract on PubMed
A.C. de Verdière, C. Dubernet, F. Nemati, E. Soma, M. Appel, J. Ferté, S. Bernard, F. Puisieux, P. Couvreur Reversion of multidrug resistance with polyalkylcyanoacrylate nanoparticles: towards a mechanism of action. Br J Cancer. 1997; 76(2): 198-205. View Abstract on PubMed.
X. Pepin, L. Attali, C. Domrault, S. Gallet, J.M. Metreau, Y. Reault, P. J.P. Cardot, M. Imalalen, C. Dubernet, E. Soma, P. Couvreur. Use of ion-pair chromatography to elucidate doxorubicin release mechanism from polyalkylcyanoacrylate nanoparticles at the cellular level. J Chromatogr B Biomed Sci Appl. 1997 Nov 21; 702(1-2): 181-91. View Abstract on PubMed.
Y.P. Hu, Sophie Jarillon, C. Dubernet, P. Couvreur, J. Robert. On the mechanism of action of doxorubicin encapsulation in nanospheres for the reversal of multidrug resistance.
Cancer Chemother Pharmacol. 1996; 37(6): 556-60. View Abstract on PubMed.
C. Cuvier, L. Roblot-Treupel, J.M. Millot, G. Lizard, S. Chevillard, M. Manfait, P. Couvreur and M.F. Poupon. Doxorubicin-loaded nanospheres bypass tumor cell multidrug resistance.
Biochem Pharmacol. 1992 Aug 4; 44(3): 509-17. View Abstract on PubMed.
J. Kattan, J.P. Droz, P. Couvreur, J.P. Marino, A. Boutan-Laroze, P. Rougier, P. Brault, H. Vranckx, J.M. Grognet, X. Morge, H. Sancho-Garnier. Phase I clinical trial and pharmacokinetic evaluation of doxorubicin carried by polyisohexylcyanoacrylate nanoparticles. Invest New Drugs. 1992 Aug; 10(3): 191-9 . View Abstract on PubMed.
N. Chiannilkulchai, N. Ammoury, B. Caillou, J.P. Devissaguet, P. Couvreur. Hepatic tissue distribution of doxorubicin-loaded nanoparticles after i.v. administration in reticulosarcoma M5076 metastasis-bearing mice. Cancer Chemother Pharmacol. 1990; 26(2): 122-6. View Abstract on PubMed.
Chiannilkulchai N, Driouich Z, Benoit JP, Parodi AL, Couvreur P. Doxorubicin-loaded nanoparticles: increased efficiency in murine hepatic metastases. Sel Cancer Ther. 1989; 5(1): 1-11. View Abstract on PubMed.
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